- 作者: Edmund C. So a, Kar-Lok Wong c, Tian-Chyuan Huang b, Sheng-Chou Tasi b, Chi-Feng Liu b
- 作者服務機構: a Department of Anesthesiology, Chi-Mei Medical Center, Tainan, b National Taipei College of Nursing, c Department of Anesthesiology, Mackay MemorialHospital, Taipei, Taiwan, ROC
- 中文摘要: --
- 英文摘要: In this study, the intraperitoneal administration of 1 mg/kg thioacetamide (TAA) produced hepatotoxicity in mice.The increase in serum SGOT and SGPT produced at 24 hby this regimen was decreased in a dose-dependentmanner by coadministration of tetramethylpyrazine(TMP; 10, 25 and 50 mg/kg). A rise in serum interleukin-2was similarly prevented. Increased concentrations ofmalondialdehyde (MDA) generated in vitro in liver ho-mogenates prepared from TAA-treated mice were de-creased by TMP treatments. The increase in MDA pro-duced by TAA was also prevented by in vitro addition ofTMP to liver homogenates. These results suggest thatpart of the hepatocellular injury induced by TAA ismediated by oxidative stress caused by the action ofcytokines through lipid peroxidation. TMP appears to actby preventing lipid peroxidation.
- 中文關鍵字: --
- 英文關鍵字: Malondialdehydem, Interleukin-2, Hepatotoxicity, Tetramethypyrazine