• 作者： 林茂村；彭玉豪；陳雲峰；陳淑瑛
• 作者服務機構： 國防醫學院生理及生物物理學系
• 中文摘要： 以藥物改變大白鼠腦中樞Catecholamine (CA)活動性並觀察其對於Chlorpromazine (CPZ)所致的降溫作用之影響(在室溫22°C之下)。以haloperidol抑低dopamine (DA)系統之傳導可減弱CPZ的降溫作用，而以apomorphine,L-DOPA或ketamine等以增強DA系統之傳導則增強CPZ的降溫作用。由此可見DA加強了CPZ的降溫作用。另一方面，Norepinephrine (NE)似可抑低CPZ的降溫作用，因為若以disulfiram來抑低NE層次則見CPZ降溫作用加強。同時，若以alpha-methyl-p-tyrosine與L-DOPA合併給予以抑低腦中樞NE層次並提高DA層次則顯著地加速CPZ的降溫作用。又，DA之作用似大於NE者，因為若以6-hydroxydoparnine來抑低DA和NE層次則減弱CPZ的降溫作用，而以L-DOPA來提高兩者的濃度則增強CPZ之降溫作用。綜合上述可見腦中樞CA在由CPZ所引起的降溫作用中扮演重要角色。
• 英文摘要： The effects of brain catecholamine (CA) on hypothermia induced by chlorpromazine (CPZ) were assessed in unanesthetized rats at room temperature (22蚓). Whereas the drug interfering with dopaminergic transmission (haloperidol) decreased the CPZ-induced hypothermia, drugs potentiating with dopaminergic transmission (apomorphine, L-DOPA and ketamine) increased the CPZ-induced hypothermia. This indicates that dopaminergic activity seems to facilitate CPZ hypothermia. Norepinephrine, on the other hand, appears to inhibit CPZ hypothermia since its selective depletion by disulfiram augmented CPZ hypothermia. Further, at a time when norepinephrine levels are known to be depressed and dopamine levels elevated (alpha-methyl-p-tyrosine plus L-DOPA), a particularly marked enhancement of CPZ hypothermia was observed. Moreover, the net effect of brain CA appears to facilitate CPZ hypothermia since depleting brain CA (6-hydroxydopamine) caused a reduction while elevating brain CA (L-DOPA) caused an increase in CPZ hypothermia. The results indicate that brain CA play a role in the elaboration or modulation of hypothermia induced by CPZ.
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