- 作者: Chih-Chun Chang; Chieh-Yu Chang; Yang-Tzu Wu; Jiung-Pang Huang; Tzung-Hai Yen; Li-Man Hung
- 作者服務機構: Department and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taiwan; R.O.C.
- 中文摘要: --
- 英文摘要:
Background: Diabetic nephropathy (DN) has been recognized as the leading cause of
end-stage renal disease. Resveratrol (RSV), a polyphenolic compound, has been
indicated to possess an insulin-like property in diabetes. In the present study, we
aimed to investigate the renoprotective effects of RSV and delineate its underlying
mechanism in early-stage DN.
Methods: The protective effects of RSV on DN were evaluated in streptozotocin
(STZ)-induced diabetic rats.
Results: The plasma glucose, creatinine, and blood urea nitrogen were significantly
elevated in STZ-induced diabetic rats. RSV treatment markedly ameliorated
hyperglycemia and renal dysfunction in STZ-induced diabetic rats. The
diabetes-induced superoxide anion and protein carbonyl levels were also significantly
attenuated in RSV-treated diabetic kidney. The AMPK protein phosphorylation and
expression levels were remarkably reduced in diabetic renal tissues. In contrast, RSV
treatment significantly rescued the AMPK protein expression and phosphorylation
compared to non-treated diabetic group. Additionally, hyperglycemia markedly
enhanced renal production of proinflammatory cytokine IL-1β. RSV reduced IL-1β
but increased TNF-α and IL-6 levels in the diabetic kidneys.
Conclusions: Our findings suggest that RSV protects against oxidative stress,
exhibits concurrent proinflammation and anti-inflammation, and up-regulates AMPK
expression and activation, which may contribute to its beneficial effects on the early
stage of DN. - 中文關鍵字: --
- 英文關鍵字: --