- 作者: 楊藏雄; 劉世智; 莊秀樹; 蕭啟方; 古筱民
- 作者服務機構: 臺北醫學院藥物化學科
- 中文摘要: 為要探究中藥稀簽(Siegesbeckia orientalis L.)有效成分,從本植物分離得一種類黃素mp. 247-249,“〔a〕31d+620 (EtOH, C一0.213)0此等物理化學諸恆數及光譜儀等分析結果及自quercetin(II)methylation所得之3, 3f, 41, 7-tetramethylquercetin(III) mp 153"--1550比較推定為3, 7-dimethylguercetin (I). 稀簽中單離得flavonoid尚屬首次“另外得無機成分硝酸鉀及二種未知構造terpenoids結晶,融點各為241-2420及1151200,其物理化學特性繼續研究中“
- 英文摘要: Investigation of Chinese drug from Siegesbeckia orientalis led to the isolation offour crystalline substances. A flavanoid, mp 247-2490,〔a〕31d+620, was assingend as3,7-dimethylquercetin(I) on the basis of its spectroscopic properties and in chemicalcorrelation with 3,3,4,7-tetramethylquercetin(III). This is the first time a flavonoidhad been isolated from Siegesbeckia orientalis. Aside from the considerable amountof inorganic salts, potassium nitrate, and two unknown terpenoids, mp 241-2420and mp 115-120 were also isolated. Siegesbeckia orientalis L. is an annual herb of Compositae and widely distributedall over Taiwan island. According to the Pentsao'), it is a well-known Chinesefolk medicine as tonic antidote and analgesics and used for treating gout, rheum-atism, anemic numbness of extremetis, weakness of knee and lumbar, deviation ofthe mouth angle and eye balls or hemiplegia, and it also has blood-pressure-reducing activity. Besides, both Siegesbeckia orientalis and its related plant, Slegesbecklapubescens, exhibit antitumor activity as reported lately by Hartwell2l. As to theconstituents, A.Diara3> et al.have isolated new compounds of diterpenol and itsglucoside, darutin and darutigenol, from this plant.In addition, K.-D. HanOreported that its related plant, Siegesbeckia pubescens, contained pimarane and kaur-ane type diterpenes and steroids. In view of the importancy of this plant as inmedicinal use and because that the chemical constituents of such plant raised inTaiwan had never been investigated yet, we were prompted to search for the activeconstituents of Siegesbeckia orientalis, The whole plant, air dried, was coarsely cut into small section. Then followedthe procedures described in the experimental part four crystalline compounds A,B, C, D were obtained.
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