• 作者： 華瑜; 陳慶鏗
• 作者服務機構： 台北榮民總醫院醫學研究部; 國立陽明醫學院藥理學研究所
• 中文摘要： 利用尾部血管間接測量法記錄血壓，本論文研究幼年雌性Sprague-Dawley大白鼠再生腎上腺皮質或腎臟切除，以及去氧腎上腺皮質胴（DOCA）或前列腺素，（PG）對腎上腺再生型高血壓之影響。實驗結果發現，單側腎臟及腎上腺切除以及對側腎上腺皮質去除，在手術後六週動物產生腎上腺再生型高血壓（P＜0.05，n=12）。此種高血壓大白鼠，如再接受腎臟切除，在此手術後12至36小時內血壓有顯著再昇高之現象。腹腔注射PG（10，20μg／kg）對此現象有抑制作用。再者，如果在腎上腺再生型高血壓大白鼠進行再生腎上腺皮質切除，在相同時問內血壓有明顯下降之趨勢，此一趨勢可因DOCA（2 mg∕kg）之處理而有減弱之現象。綜合實驗結果，我們推論再生之腎上腺皮質及腎臟在腎上腺再生型高血壓之產生及維持上扮演重要角色。腎上腺再生型高血壓之維持可能是因再生之腎上腺皮質分泌DOCA而產生，此一作用又受腎臟分泌之PG平衡。
• 英文摘要： The involvement of the regenerating adrenal gland and kidney, and the contribution of deoxycor-ticosterone (DOC) and prostaglandin (PGE), in the development of adrenal regeneration hypertension(ARH) was evaluated in young female Sprague-Dawley rats. Based on tail-cuff plethysmographic measure-ment, animals subjected to nephrectomy and adrenalectomy on the right side and adrenal enucleation(removal of the adrenal cortex) on the left side developed significant (P<0.05, n=12) hypertension within6 weeks following operation. Subsequent left nephrectomy in these ARH rats produced a further elevation,whereas a secondary adrenalectomy resulted in an acute and discernible reduction in blood pressure within24-36 hours. It is interesting to note that the progressive increase in blood pressure following left nephrectomywas significantly reversed by PGE (10 or 20 μg/kg, i.p.). At the same time, the reduction in blood pressureafter secondary adrenalectomy was significantly retarded by deoxycorticosterone trimethylacetate (2 mg/kg,i.P.). These data demonstrated that both the kidney and the regenerating adrenal cortex are involved inthe pathogenesis of ARH. Furthermore, it is probable that the secretion of DOC by the regenerating adrenalcortex is responsible for the elevation in blood pressure, in a process that is balanced by PGE, possiblysecreted by the kidney.
• 中文關鍵字： adrenal regeneration hypertension; adrenalectomy; nephrectomy; deoxycorticosterone trimethylacetate; prostaglandin E2; rat.
• 英文關鍵字： --