- 作者: Saara Lehtinen Vappu Rantalaiho Ole Wirta Amos Pasternack Pekka Laippala Timo Koivula Terho Lehtimaki
- 作者服務機構: Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Department of Internal Medicine, School of Public Health, University of Tampere and Research Unit, Tampere University Hospital, Department of Clinical Chemistry, Medical School of Tarmpere University, Tampere, Finland
- 中文摘要: --
- 英文摘要:
Objective: To study the association between apolipopro-
tein E (apoE) genotype and the rate of decline in glomer-
ular filtration rate (GFR) in type 2 diabetic patients in a
9-year prospective study. Methods: GFR was determined
in 84 type 2 diabetic patients by plasma clearance of 51Cr-
EDTA at baseline and after 9 years of follow-up. ApoE
genotypes were determined by polymerase chain reac-
tion and restriction enzyme Hhal digestion and designat-
ed as s4 allele group ( apoE4/2, 4/3 and 4/4 genotypes; n=
20) and non-s4 allele group (apoE3/3 and E3/2 geno-
types; n=64). We focused our analysis on those patients
who were more likely to progress to diabetic renal dis-
ease, I.e. whose GFR fell more than expected in the nor-
mal course of ageing [1 ml x min-1 x (1.73 m2)-1 per
year]. Results: In the whole population,the decline in the
GFR did not differ statistically significantly between the
apoE genotype groups [p=0.65 with analysis of variance
for repeated variables (RANOVA) for interaction between
apoE genotype group and time point]. However, among
patients whose GFR changed more than 9 ml x min-1 x
(1.73 m2)-1,GFR showed a statistically significantly
greater decline in the s4 allele group (n=11) than in the
non-a4 allele group (n=43) [from 116±36 to 80±29 ml
x min-1 x (1.73 m2)-1 vs. from 119±20 to 96±18 ml x
min-1 x (1.73 m2)-1:P=0.005 with RANOVA]. Conclu-
sion: ApoE allele s4 may speed up the rate of decline of
the GFR in patients with progressive diabetic renal dis-
ease. - 中文關鍵字: --
- 英文關鍵字: Apolipoprotein E. Nephopathy. Type 2 Diabetes. Glomerular filtration rate