- 作者: Cory G. Acuff; Glenn Hoskins; N. Anthony Moore; Robin W. Rockhold
- 作者服務機構: Departments of; a Pharmacology and Toxicology and ; b Anatomy, University of Mississippi Medical Center, Jackson, Miss., USA
- 中文摘要: --
- 英文摘要: The purpose of the present study was to demonstrate, using a vascular casting technique, acute vasoconstrictive changes in the cerebral vasculature 1 h following whole-blood or plasma infusion into the subarachnoid space of conscious spontaneously hypertensive rats. Vascular casts from animals infused (over 20 min) with 0.45 ml of heparinized autologous arterial blood or plasma exhibited incomplete filling, while casts from saline-infused controls exhibited virtually no filling defects. Significant elevations in intracranial pressure were noted in blood, but not in plasma- or saline-infused rats. Two characteristic forms of constriction occurred, depending upon the vessel lumen diameter. Vessels with lumen diameters >100 μm were flattened longitudinally with deep endothelial nuclear imprints, while smaller vessels had focal circular constrictions resembling beads. Arterial cast filling terminated in vessels with lumen diameters from 70 to 20 μm with focal signs of constriction at or near the point of cast termination. The results indicate that the presence of both blood and plasma in the subarachnoid space produces acute small-artery constriction. This phenomenon is due to a noncellular blood component and does not correlate with increases in intracranial pressure.
- 中文關鍵字: --
- 英文關鍵字: Subarachnoid hemorrhage ; Spontaneously hypertensive rat ; Vasospasm; Cerebral vasoconstriction ; Vascular casting