- 作者: 田憲儒 ; 蔡炎烘 ; 葉文淵 等
- 作者服務機構: 成功大學化學系
- 中文摘要:
Two new sydnones; 3-(o-methoxybenzyl)sydnone(1) and 3-(o-methoxybenzyl)-4-morpholinomethylsydnone(2) were synthesized from o-methoxybenzylamine and ethyl bromoacetate in moderate yields.
3-(o-,m-,p-Fluorophenyl)sydnones were prepared from the corresponding fluoroaniline and chloroacetic acid in higher yields with a conventional method.
From the biological activity test, 1 shows significant response of coronary dilation test, collagen induced platelet aggregation inhibition, local anesthetic and moderate cardiotropic activity. In addition, 1 also leads to anticonvuls, muscle relaxation and behavior depression. But 2 only shows inhibition of collagen induced platelet aggregation and antiwrithing.
3-(p- Fluorophenyl)sydnone shows significant response of coronary dilation, collagen induced platelet aggregation inhibition, moderatc cardiotropic activity, antiwrithing and local anesthetic. But 3-(o-Fluorophenyl)sydnone and 3-(m-fluorophenyl)sydnone only show coronary dilation and moderate cardiotropic activity. - 英文摘要: --
- 中文關鍵字: 3-(O-Methoxybenzyl)Sydnone; 3-(O-Methoxybenzyl)-4-Morpholinomethylsydnone; 3-(Fluoro Phenyl)Sydnone; Biological Activi
- 英文關鍵字: 3-鄰甲氧基雪梨酮;3-鄰甲氧基-4-嗎甲基雪梨酮;3-氟基雪梨酮;生物活性;冠狀動脈擴張;血小板凝結作用;局部麻醉;抗痙攣;肌肉鬆弛