- 作者: Kwang-Hyun Baek Kwang-Youl Lee
- 作者服務機構: Division of Pediatric Oncology and Department of Adult Oncology. dana Farber cancer Institute, Harvard Medical School, Boston, Mass., USA
- 中文摘要: --
- 英文摘要: In Drosophila, the establishment of embryonic polarityalong the anterior-posterior axis of the egg is determinedby the activity of maternal gene products that accumu-late during oogenesis. Amongst these are the Bicoid, theNanos, and the terminal class gene products, some ofwhich are oncoproteins involved in signal transductionfor the formation of terminal structures in the embryo.Several signal transduction pathways have been de-scribed in Drosophila, and this review explores the po-tential of oncogene studies using one of those pathways-the terminal class signal transduction pathway-to bet-ter understand the cellular mechanisms of proto-onco-genes that mediate cellular responses in vertebratesincluding humans.
- 中文關鍵字: --
- 英文關鍵字: Signal transduction. receptor tyrosine kinase. Oncogene. Raf