- 作者: Chun-Hsu Cheng; Feng-Ming Lin; Yu-Hui Lo; Ting-Fang Wang
- 作者服務機構: 1 Institute of Biological Chemistry, Academia S璯ica, Taipei, 115, Taiwan; ; 2 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 114, Taiwan
- 中文摘要: --
- 英文摘要: In budding yeast Saccharomyces cerevisiae, centromeres and telomeres are tethered to the nuclear envelope during premeiotic interphase. Immediately after cells enter meiotic prophase, chromosomes undergo global reorganization, including bouquet formation (telomere clustering), non-homologous centromere coupling, homologous pairing, and assembly/disassembly of synaptonemal complexes. These chromosome dynamics have been implicated in promoting pairing, synapsis, crossover DNA recombination and segregation between homologous chromosomes. This review discusses recent studies related to the role of small ubiquitin-like modifier (SUMO) modification in controlling the overall budding yeast chromosome dynamics during meiotic prophase.
- 中文關鍵字: --
- 英文關鍵字: meiosis, SUMO, synaptonemal complex, homologous recombination, telomere, centromere