- 作者: Nien-Chung Yang ; Samuel H.H. ; Chan Julie Y.H. Chan
- 作者服務機構: a Department of Medical Research, Veterans General Hospital, Taipei, and; b Center for Neuroscience, National Yang-Ming University, Taipei, Taiwan
- 中文摘要: --
- 英文摘要: We evaluated the potential participation of galanin (GAL) at the paraventricular nucleus of hypothalamus (PVN) in the suppression of baroreceptor reflex (BRR) response by locus ceruleus (LC), using adult male Sprague-Dawley rats anesthetized with pentobarbital sodium. Microinjection of GAL (100 pmol) bilaterally into the PVN significantly depressed the BRR response. This suppressive effect was appreciably antagonized when GAL (100 pmol) and GAL antiserum (1:20) were coadministered into the bilateral PVN. Whereas bilateral microinjection of GAL antiserum into the PVN by itself elicited minimal effect, it nevertheless significantly attenuated the suppressive effect of either electrical or chemical activation of LC on the BRR response. Pretreatment with the same amount of normal rabbit serum (1:20), on the other hand, was ineffective. These results suggest that a galaninergic projection from the LC to PVN may participate in the suppression of BRR response by this dorsal pontine nucleus.
- 中文關鍵字: --
- 英文關鍵字: Galanin ; Locus ceruleus ; Paraventricular nucleus of hypothalamus ; Baroreceptor reflex response ; Galanin antiserum ; Nucleus tractus solitarii