- 作者: --
- 作者服務機構: Department of Chemistry, Faculty of Sciences, Azad University of Arak, Arak, Iran
- 中文摘要: A new adsorptive anodic differential pulse stripping voltammetry method for the direct determination of noscapine at trace levels in human plasma of addicts is proposed. The procedure involves an adsorptive accumulation of noscapine on a hanging mercury drop electrode (HMDE), followed by oxidation of adsorbed noscapine by voltammetry scan using differential pulse modulation. The optimum conditions for the analysis of noscapine are pH = 8.5 using Britton-Robinson (B-R) buffer, accumulation potential of -100 mV (vs. Ag/AgCl), and accumulation time of 150 s. The peak current is proportional to the concentration of noscapine, and a linear calibration graph is obtained at 0.015-2.75 μg mL-1. A relative standard deviation of 1.28% (n = 5) was obtained, and the limit of detection was 7 ng mL-1. The capability of the method for the analysis of real samples was evaluated by determination of noscapine in spiked human plasma and addicts, human plasma with satisfactory results.
- 英文摘要: --
- 中文關鍵字: Noscapine; Adsorptive cathodic differential pulse voltammetry; Human plasma.
- 英文關鍵字: --