- 作者: Dan Nie, Yue Hu, Zhou Chen, Mingkai Li, Zheng Hou, Xiaoxing Luo, Xinggang Mao and Xiaoyan Xue
- 作者服務機構: 1. Department of pharmacology, Fourth Military Medical University, Xi’an, China 2. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China
- 中文摘要:
- 英文摘要:
Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target. - 中文關鍵字:
- 英文關鍵字: A. baumannii, AbOmpA, Infection, Therapeutic target, Multidrug-resistant