- 作者: 楊炳炘; 陳光和; 林瑞雄
- 作者服務機構: 中央研究院嚴族學研究所博士後助研究員; 國立臺灣大學醫學院公共衛生研究所
- 中文摘要: 臺灣地區的B-型肝炎感染非常盛行,在判讀常人群體的血清生化學健康篩檢數據時,除了性別之外,B-型肝炎病毒表面抗原標誌也應該作為區分「子群體」的要素,以提高健康篩檢的鑑別力。本研究收集臺灣中部地區2157位在學青少年的11項血清生化檢驗值,以性別和B-型肝炎表面抗原標誌兩因子作為自變項,分別對每一項目進行雙因子變異數分析(two-way ANOVA)。除了uric acid一項之外,兩因子的交叉效果,在各項目都未達到顯著水準(p>0.05),所以性別和B-型肝炎血清標誌是兩個獨立的因子。B-型肝炎表面抗原的主效果,在7項肝臟功能有關的血清生化檢驗項目:total protein、albumin、total cholesterol、alkaline phosphatase、aspartate aminotransferase、alanineaminotransferase、lactate dehydrogenase等,分別都已經達到顯著水準(p<0.05)。 B-型肝炎表面抗體個別的主效果,對所有11項目,都未達到顯著水準。在性別的主效果方面,除了BUN一項之外,肯定其他的血清生化學檢驗值,都具有性別的差異。研究群體的年齡在14-17歲之間;其中有男生599人、女生1558人,全部都不曾接種過B-型肝炎疫苗。
- 英文摘要: With ages between 14-17 years, none of the 2157 subjects studied in the central Taiwan area hadever been inoculated with the hepatitis B vaccine. Whether a hepatitis B virus surface variable, either thehepatitis B surface antigen (HBsAg) or its antibody (anti-HBs), was an interpretation factor in reading labora-tory data for a common serum biochemical test was analyzed by two-way analysis of variance (ANOVA).The two independent variables were gender and the hepatitis B surface variable. Either HBsAg or pairedHBsAg/anti-HBs was a necessary factor for the seven items: total protein, albumin, total cholesterol, alkalinephosphatase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Anti-HBsalone was not an effective agent for the above seven tests and four additional tests, blood urea nitrogen,uric acid, creatinine, and total bilirubin. The analyses yielded no interaction between gender and eitherhepatitis B surface variable for all tests except uric acid.
- 中文關鍵字: serum biochemical screening; HBsAg; two-way ANOVA; young adult
- 英文關鍵字: --