- 作者: Feng-Ming Tien, Hsuan-Hsuan Lu, Shu-Yung Lin & Hsing-Chen Tsai
- 作者服務機構: 1.Center for Frontier Medicine, National Taiwan University Hospital, Taipei, 100225, Taiwan 2.Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100225, Taiwan 3.Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, 100233, Taiwan 4.Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1 Jen Ai Road Section 1, Rm542, Taipei, 100233, Taiwan
- 中文摘要:
- 英文摘要:
The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes
communicate with cancer cells and stromal cells. The dynamic cellular composition and functional characteristics
of the immune landscape along the trajectory of cancer development greatly impact the therapeutic efcacy and
clinical outcome in patients receiving systemic antitumor therapy. Mounting evidence has suggested that epigenetic
mechanisms are the underpinning of many aspects of antitumor immunity and facilitate immune state transitions
during diferentiation, activation, inhibition, or dysfunction. Thus, targeting epigenetic modifers to remodel the
immune microenvironment holds great potential as an integral part of anticancer regimens. In this review, we sum‑
marize the epigenetic profles and key epigenetic modifers in individual immune cell types that defne the functional
coordinates of tumor permissive and non-permissive immune landscapes. We discuss the immunomodulatory roles
of current and prospective epigenetic therapeutic agents, which may open new opportunities in enhancing cancer
immunotherapy or overcoming existing therapeutic challenges in the management of cancer. - 中文關鍵字:
- 英文關鍵字: Tumor immune microenvironment, Epigenetic therapy, Immunotherapy, DNA methylation, Histone modifcations, Chromatin accessibility, Innate immunity, Adaptive immunity