- 作者: Chih-Yang Huang; Li-Chiu Yang; Kuan-Yu Liu; I-Chang Chang; Pao-Hsin Liao; Janet Ing-Yuh Chou; Ming-Yung Chou; Wei-Wen Lin; Jaw-Ji Yang
- 作者服務機構: Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell
migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that
RhoGDIβ plays a previously undefined role in regulating Rac1 expression through
transcription to induce hypertrophic growth and cell migration and that these
functions are blocked by the expression of a dominant-negative form of Rac1. We
also demonstrated that knockdown of RhoGDIβ expression by RNA interference
blocked RhoGDIβ-induced Rac1expression and cell migration. We demonstrated that
the co-expression of ZAK and RhoGDIβ in cells resulted in an inhibition in the
activity of ZAK to induce ANF expression. Knockdown of ZAK expression in
ZAK-RhoGDIβ-expressing cells by ZAK-specific RNA interference restored the
activities of RhoGDIβ. - 中文關鍵字: --
- 英文關鍵字: --