第6卷‧第2期,
198204
, pp. 226-234
獼候經大腦穹窿手術處理後之空間記憶
- 作者:
尹在信
- 作者服務機構:
國防醫學院生理及生物物理學系; 榮民總醫院醫學研究部
- 中文摘要:
本實驗探討嫻猴大腦穹窿經手術處理前後之空間記憶。為此設計一3層木板架,每層有3個置食餌之小井,共9個,上覆相同之圓形木蓋。令動物在威大箱內作9次分隔的選擇,是為一節測驗。如此逐日訓練至動物能在9次中有7次成功,即獲得食餌,便認為達到標準。然後繼續測驗10天,每天3節,共計30節,因每節9次,故選擇總數為270 。此時施以手術,俟恢復後再重覆操作,以與手術前的成績相比較。在12隻動物中,6隻接受二期手術:一次為植入圍繞穹窿之套結,再次為拉出套結以割斷穹窿;3隻施以一次切斷穹窿之手術;其餘3隻將胼胝體與穹窿作中線剖分以資對照。結果發現僅作穹窿套結即足以影響空間行為,似與一次切斷穹窿無異,而且套結之拔除並未使之更形退步,至於胼胝體與穹窿自中線剖分之對照動物組則與手術前相較並無明顯之變化。所得結論為同意綠腦系統與空間行為密切相關之觀點,並提出穹窿套結對獼猴空間功能有不利影響之現象。
- 英文摘要:
Spatial memory was studied in the monkey before and after surgical manipulation of the fornix.For this purpose, a rack composed of 3 tiers of board with 9 baited wells beneath identical covers wasdesigned, allowing the partially food-deprived animal to make 9 separate choices in each session. After theanimal had been trained to criterion, which was 7 rewarded trials out of 9, a course of 30 sessions in 10days with a total of 270 trials was given before the operation, and postoperative retaining of this task wastested by repeating the procedures in due time. In the 12 animals used, 6 received the operation in 2stages: ensnaring of the fornix and later lifting of the snare to transect it; 3 animals received acute transec-tion of the fornix; and the 3 control animals received midline division of the corpus callosum and the fornixwithout severing it. Results revealed that the very practice of ensnaring the fornix impaired the spatialbehavior just as much as the acute transection of the fornix and that lifting of the snare did not worsenthe performance. On the other hand, midline division of the corpus callosum as well as the fornix had noadverse effect save for some transient influence. The results corroborate those of other investigators thatthe limbic system is involved in spatial behavior and indicate that the mere implantation of a snare aroundthe fornix is sufficient to disrupt the spatial function.
- 中文關鍵字:
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- 英文關鍵字:
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