- 作者: Shian-Ling Ding; Lai-Fa Sheu; Jyh-Cherng Yu; Tseng-Long Yang; BeFong Chen; Fur-jiang Leu; Chen-Yang Shen
- 作者服務機構: Gaduate Institute of Life Sciences, National Defense Medical Center, Institute of Biomedical Sciences, Academia Sinica, Department of Nursing, Kang-Ning Junior Colloge of Medical Care and Management, Department Pathology and Surgery, Tri-Service General Hospital, National Defense Medical Center, Department of Surgery and Pathology, Mackay Memorial Hospital, and Section of Pathology, Cardinal Tien Hospital and Fu-Jen Catholic Universtiy Taipei, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Estrogen causes breast cancer by triggering proliferationvia an estrogen receptor(ER)-mediated mechanism.However, paradoxically, ERα,one of the two known ERsubtypes, and the proliferation marker, Ki67, are notusually expressed in the same breast tumor. To explorewhether ERα-positive tumors and proliferating(Ki67-positive) tumors have different tumorigenic characteris-tics, we performed an immunohistochemical study on 74early-onset infiltrating ductal carcinomas of the breast.To test this hypothesis, we examined whether ERα-posi-tive and Ki67-positive tumors showed differences in(i)pathological grade,(ii)three indices of tumor grade (tu-bule formation,nuclear pleomorphism,and mitotic num-ber),and(iii)expression of important proteins implicatedin breast tumorigenesis (cyclin D1,ErbB2,ATM,BRCA1,Rb, p53, and p21).The results of the multigenic analysisshowed that ERα and Ki67 were the only two importantmarkers significantly and independently associated withtumor grade, consistent with the above hypothesis.ERα-positive, Ki67-negative tumors frequently displayed alow tumor grade(i.e.being well differentiated),whereasKi67-positive, ERα -negative tumors were more likely toexhibit a high tumor grade.In addition,positive ERα expression(46 of 74 cases, 62%)correlated well withpositive cyclin D1 expression (p<0.005),less nuclearpleomorphism(p<0.001),and a low mitotic count (p<0.005),whereas positive Ki67 expression (36 of 74 cases,49%)correlated with reduced BRCA1 expression(p<0.01)and high mitotic activity(p<0.01).These findingssuggest that the expressions of ERα and Ki67 might beinvolved in distinct pathological and molecular featuresduring breast cancer development.
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