- 作者: Shalaby, Alyaa A. ; Youssef, Ali M. ; Youssef, Wael A. et al.
- 作者服務機構: Chemistry Dept., Ain Shams Univ., Abbassia, Cairo, A.R. Egypt
- 中文摘要: 4H,5H-6-Phenyl and 6-p-phenoxyphenyl pyridazin-3(2H)- ones were reacted with aromatic aldehydes to give 4- arylmethylpyridazin-3(2H)-ones (2a-g). Oxidation of (2a-g) with various oxidizing agents (selenium dioxide in ethanol or chromium trioxide in acetic acid) gave 4-aroyl-6- arylpyridazin-3(2H)-ones (3a-g). Chlorination of (3a-g) with phosphorous oxychloride afforded 4-aroyl-6-aryl-3- chloropyridazine (4a-g). 1H-3-Aryl-5-phenylpyrazolo [ 3,4-c] pyridazines were obtained by heating (4a-d) with excess hydrazine hydrate. Hydroxyamination of (3e-g) with hydroxylamine gave aryl-4(6-p-phenoxyphenyl-2,3-dihydro-3- oxo)pyridazinyl oxime (6a-c). Silylation of oximes (6b & 6c) gave (7a & 7b) as acyclic compound instead of the expected seven- membered-ring compound.
- 英文摘要: --
- 中文關鍵字: Synthesis; Pyridazine; Selenium Dioxide; Chromium Trioxide; Chlorination; Hydroxyamination
- 英文關鍵字: 合成;嗒;二氧化硒;三氧化鉻;氯化;羥胺化