- 作者: Varinder K Lall, Mathias Dutschmann, Jim Deuchars; Susan A Deuchars
- 作者服務機構: School of Biomedical Sciences, University of Leeds, Leeds, UK
- 中文摘要: --
- 英文摘要:
Background: Mefloquine is an anti-malarial drug that can have neurological side effects. This study
examines how mefloquine (MF) influences central nervous control of autonomic and
respiratory systems using the arterially perfused working heart brainstem preparation of the
rat.
Recordings of nerve activity were made from the thoracic sympathetic chain and phrenic
nerve, while heart rate (HR) and perfusion pressure were also monitored in the arterially
perfused, decerebrate, rat WHBP. MF was added to the perfusate at 1 μM to examine its
effects on baseline parameters as well as baroreceptor and chemoreceptor reflexes.
Results: MF caused a significant, atropine resistant, bradycardia and increased phrenic nerve
discharge frequency. Chemoreceptor mediated sympathoexcitation (elicited by addition of
0.1 ml of 0.03% sodium cyanide to the aortic cannula) was significantly attenuated by the
application of MF to the perfusate. Furthermore MF significantly decreased rate of return to
resting HR following chemoreceptor induced bradycardia. An increase in respiratory
frequency and attenuated respiratory-related sympathetic nerve discharge during
chemoreceptor stimulation was also elicited with MF compared to control. However, MF did
not significantly alter baroreceptor reflex sensitivity.
Conclusions: These studies indicate that in the WHBP, MF causes profound alterations in autonomic and
respiratory control. The possibility that these effects may be mediated through actions on
connexin 36 containing gap junctions in central neurones controlling sympathetic nervous
outflow is discussed. - 中文關鍵字: --
- 英文關鍵字: Mefloquine, Malaria, Sympathetic, Connexin, Respiratory