- 作者: Ladan Edjlali
- 作者服務機構: Laboratory of Organic Chemistry Research, Department of Applied Chemistry, Islamic Azad University, Tabriz Branch, P. O. Box 1655, Tabriz, Iran
- 中文摘要: The compounds with isoxazole moiety have many pharmacological, biological and industrial applications, specifically their antiviral activity. In this research work, seven new compounds of 3,5-disubstituted isoxazoles were synthesized. Propargyl alcohol (1) reacted with benzoyl chloride to give propargylphenylcarboxylate (2). Then, the aldehydes (3a-3g) were converted to the related oximes (4a-4g) and nitrileoxides in situ by NaOCl, consequently. Reaction of compound 2 with nitrileoxides in a [3+2] cycloaddition reaction gave regiospecifically isoxazoles (5a-5g). 1H NMR, 13C NMR, FT-IR, and elemental analyses confirmed the structure of the synthesized compounds.
- 英文摘要: --
- 中文關鍵字: Isoxazoles; Propargyl alcohol; [3+2] cycloaddition.
- 英文關鍵字: --