- 作者: Levi HC Makala
- 作者服務機構: Georgia Health Sciences University, Medical College of Georgia, Department of Pediatrics, Hematology/oncology Section, Augusta, Georgia, USA
- 中文摘要: --
- 英文摘要:
Pathogen persistence in immune-competent hosts represents an immunological
paradox. Increasing evidence suggests that some pathogens, such as, Leishmania major (L.
major) have evolved strategies and mechanisms that actively suppress host adaptive immunity.
If this notion is correct conventional vaccination therapies may be ineffective in enhancing host
immunity, unless natural processes that suppress host immunity are also targeted
therapeutically. The key problem is that the basis of pathogen persistence in immune-competent
individuals is unknown, despite decades of intense research. This fact, coupled with poor health
care and a dearth of effective treatments means that these diseases will remain a scourge on
humans unless a better understanding of why the immune system tolerates such infections
emerges from research. Indoleamine 2,3-dioxygenase (IDO) has been shown to act as a
molecular switch regulating host responses, and IDO inhibitor drugs shown to possess potential
in enhancing host immunity to established leishmania infections. It is hoped that this review will
help stimulate and help generate critical new knowledge pertaining to the IDO mechanism and
how to exploit it to suppress T cell mediated immunity, thus offer an innovative approach to
studying the basis of chronic leishmania infection in mice. - 中文關鍵字: --
- 英文關鍵字: Leishimania major, Indoleamine 2,3-dioxygenase, Mice, Leishmaniasis, Host Immunity, 1- methyl-d-tryptophan, plasmacytoid dendritic cell, regulatory T cell, draining lymph node