- 作者: 許光淦; 孫紹文; 陳岳鴻
- 作者服務機構: School of Pharmacy, National Taiwan University, Taipei, Taiwan 100
- 中文摘要: In continuing search of the structure-activity relationship of heterocyclic chromones, 4-quiolyl and 3-quinoltl moieties were each introduced to the C-2 position of chromones, A total of 12 quinolyl moieties were synthesized. 4-Quinolinecarboxaldehyde was condensed with 2-hydroxyacetophenones to provide the chalcones. These intermediates were then subjected to selenium dioxide dehydrogenation to yield the 6 new 4-quanolyl chromones. 3-Quinolinecarboxaldehyde was condensed with 2-hydroxyacetophenones in the presence of dilute alkali to give aldol compounds of chalcones (dehydration products of aldols). Ring cyclization of the chalcones yielded the other 6 new 3-quinolyl chromones.
- 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --