- 作者: Ning-Sun Yang; Lie-Fen Shyur; Chih-Huai Chen; Sheng-Yang Wang; Chi-Meng Tzeng
- 作者服務機構: Institute of BioAgricultural Sciences, Academia Sinica, Department of R&D, U-Vision Biotech Inc., Taipei, Department Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Metabolite profiling and DNA microarray analysis ofglobal gene expression profiles were employed to char-acterize the bioactivities of the herbal extract of Anoecto-chilus formosanus (AF), a popular folk medicine withanticancer activity, in MCF-7 cancer cells. The pharmaco-genomic activities of this plant extract as a crude phyto-compound mixture were compared to those conferredby the single-compound drug,plumbagin. A similar levelof complexity in transcriptional regulation at the ge-nomic level was observed for both AF extract- and plum-bagin-treated MCF-7 cells, as revealed by the number ofup- or downregulated genes as well as by the specific butdistinct patterns found in the gene-clustering analysis.This finding offers evidence to support the search forfractionated medicinal herb extracts or phytocompoundmixtures, in addition to single-compound drugs, as de-fined therapeutic agents.
- 中文關鍵字: --
- 英文關鍵字: --