- 作者: Jehad M Al-Shuneigat; Samir S Mahgoub; Fazlul Huq
- 作者服務機構: Faculty of Medicine, Department of Pharmacology and Biochemistry Mu'tah University, Al Karak, Jordan
- 中文摘要: --
- 英文摘要:
Background: Colorectal carcinoma is a common and often fatal disease in which methods of early detection
and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes,
carcinoembryonic antigen (CEA) and CA 19-9 in patients newly diagnosed with colorectal carcinoma and
confirmed by clinicopathological study. Method: Thirty subjects were included in the current study: six normal subjects as a control group with mean age (45.6 ± 7.9) and twenty four colorectal carcinoma patients
with mean age (46.9 ± 15.6), which were classified pathologically according to the degree of malignant cell
differentiation into well differentiated (group I), moderately differentiated (group II) and poorly
differentiated (group III). Fasting venous blood samples were collected preoperative. Results: The results
revealed a significant increase in serum level of nucleosomes in patients with poorly differentiated tumors
versus patients with well differentiated tumors (p = 0.041). The levels of CEA and CA19-9 showed no
significant increase (p = 0.569 and 0.450, respectively). Conclusion: In conclusion, serum level of
nucleosomes provides a highly sensitive and specific apoptotic marker for colorectal carcinoma. - 中文關鍵字: --
- 英文關鍵字: colorectal carcinoma, nucleosomes, carcinoembryonic antigen (CEA) and CA 19-9, tumor marker