- 作者: Tsung-Ping Su
- 作者服務機構: Cellular Pathobiology Unit, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse/NIH, Baltimore, Md,. USA
- 中文摘要: --
- 英文摘要: By studying the hibernation in ground squirrels, a pro-tein factor termed hibernation induction trigger (HIT)was found to induce hibernation in summer-activeground squirrels. Further purification of HIT yielded an88-kD peptide that is enriched in winter hibernator. Par-tial sequence of the 88-kD protein indicates that it may berelated to the inhibitor of metal loproteinase. Delta opioid[D-AIa ,D-Leu ]enkephalin (DADLE) also induced hiber-nation. HIT and DADLE were found to prolong survival ofperipheral organs preserved en bloc or as a single prepa-ration. These organs include the lung, the heart, liver andkidney. DADLE also promotes survival of neurons in thecentral nervous system. Methamphetamine (METH) isknown to cause destruction of dopaminergic(DA) ter-minals in the brain. DADLE blocked and reversed theDA terminal damage induced by METH. DADLE actedagainst this effect of METH at least in part by attenuatingthe mRNA expressions of a tumor necrosis factor p53and an immediate early gene c-fos. DADLE also blockedthe neuronal damage induced by ischemia-reperfusionfollowing a transient middle cerebral artery occlusion. InPC12 cells, DADLE blocked the cell death caused byserum deprivation in a naltrexone-sensitive manner.Thus, DADLE, and by extension the endogenous deltaopioid peptides and delta opioid receptors, may play animportant role in organ and neuronal survival. Here, criti-cal developments concerning these fascinating cell pro-tective properties of DADLE are reviewed.
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- 英文關鍵字: --