- 作者: Shahrooz Vahedi; Mehrnoosh Rajabian; Arman Misaghian; Daniel Grbec; Horst H Simon; Kambiz N Alavian
- 作者服務機構: The Baha'i Institute for Higher Education (BIHE), Tehran, Iran
- 中文摘要: --
- 英文摘要:
Background: Parkinson’s disease is the second most common neurodegenerative
disorder. The pathological hallmark of the disease is degeneration of midbrain
dopaminergic neurons. Genetic association studies have linked 13 human chromosomal
loci to Parkinson’s disease. Identification of gene(s), as part of the etiology of
Parkinson’s disease, within the large number of genes residing in these loci can be
achieved through several approaches, including screening methods, and considering
appropriate criteria. Since several of the indentified Parkinson’s disease genes are
expressed in substantia nigra pars compact of the midbrain, expression within the
neurons of this area could be a suitable criterion to limit the number of candidates and
identify PD genes.
Methods: In this work we have used the combination of findings from six rodent
transcriptome analysis studies on the gene expression profile of midbrain dopaminergic
neurons and the PARK loci in OMIM (Online Mendelian Inheritance in Man) database,
to identify new candidate genes for Parkinson’s disease.
Results: Merging the two datasets, we identified 20 genes within PARK loci, 7 of which
are located in an orphan Parkinson’s disease locus and one, which had been identified
as a disease gene. In addition to identifying a set of candidates for further genetic
association studies, these results show that the criteria of expression in midbrain
dopaminergic neurons may be used to narrow down the number of genes in PARK loci
for such studies. - 中文關鍵字: --
- 英文關鍵字: --