- 作者: Chien-Hui Chien and Bor-Luen Chiang
- 作者服務機構: 1. Graduate Institute of Clinical Medicine, National Taiwan University, Taipei City 10048, Taiwan, Republic of China 2. Department of Medical Research, National Taiwan University Hospital, Taipei City 10002, Taiwan, Republic of China
- 中文摘要:
- 英文摘要:
Regulatory T cells play a crucial role in the homeostasis of the immune response. In addition to CD4+Foxp3+ regulatory T cells, several subsets of Foxp3- regulatory T cells, such as T helper 3 (Th3) cells and type 1 regulatory T (Tr1) cells, have been described in mice and human. Accumulating evidence shows that naïve B cells contribute to tolerance and are able to promote regulatory T cell differentiation. Naïve B cells can convert CD4+CD25- T cells into CD25+Foxp3- regulatory T cells, named Treg-of-B cells by our group. Treg-of-B cells express LAG3, ICOS, GITR, OX40, PD1, and CTLA4 and secrete IL-10. Intriguingly, B-T cell-cell contact but not IL-10 is essential for Treg-of-B cells induction. Moreover, Treg-of-B cells possess both IL-10-dependent and IL-10-independent inhibitory functions. Treg-of-B cells exert suppressive activities in antigen-specific and non-antigen-specific manners in vitro and in vivo. Here, we review the phenotype and function of Foxp3+ regulatory T cells, Th3 cells, Tr1 cells, and Treg-of-B cells. - 中文關鍵字:
- 英文關鍵字: Regulatory T cells, Lymphocyte-activation gene 3, Programmed cell death protein 1, Inducible T-cell co-stimulator, Interleukin 10, Cytotoxic T lymphocyte-associated antigen-4, Treg-of-B cells