- 作者: 許華麟,吳欣玲,文迦生,陳焜銘
- 作者服務機構: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 116, R.O.C.
- 中文摘要: The diastereoselective cyanation of a-keto amides using trimethylsilyl cyanide in the presence of a Lewis acid is described. The corresponding O-acetylated cyanohydrins are obtained in good to high levels of stereoselectivities. The predominance of products with the S absolute configuration at the newly generated stereogenic center was deduced from single crystal X-ray analysis. 13C NMR data suggest that a preferential s-cis conformation was formed by the chelation of a Lewis acid to the dicarbonyl oxygen atoms.
- 英文摘要: --
- 中文關鍵字: Diastereoselective; Chiral auxiliary; Cyanation; a-Ketoamides; Timethylsilyl cyanide; Lewis acid.
- 英文關鍵字: --