- 作者: Kuo-Cheng Lan; Tangeng Ma; Shoei-Yn Lin-Shiau; Shing-Hwa Liu; Ing-Kang Ho
- 作者服務機構: 1 Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kong Road, Taipei, 114, Taiwan, ROC; ; 2 Department of Toxicology, College of Medicine, National Taiwan University, No. 1, Section I, Jen-Ai Road, Taipei, 100, Taiwan, ROC; ; 3 Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA; ; 4 Department of Pharmacology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, 100, Taiwan, ROC; ; 5 Division of Mental Health and Substance Abuse Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli, 350, Taiwan, ROC
- 中文摘要: --
- 英文摘要: μ-Opioid receptors (μ-ORs) modulate methamphetamine (MA)-induced behavioral responses, increased locomotor activity and stereotyped behavior in the mouse model. We investigated the changes in dopamine (DA) and serotonin (5-HT) metabolism in the striatum following either acute or repeated MA treatment using in vivo microdialysis. We also studied the role of μ-ORs in the modulation of MA-induced DA and 5-HT metabolism within μ-OR knockout mice. Subsequent to either acute or repeated intraperitoneal administration of M A, wild-type mice revealed decreases in extracellular concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner. Moreover, wild-type mice had reductions in basal concentrations of DOPAC and HVA following repeated MA treatment with a higher dose. The effects of acute, repeated or challenge MA administration upon extracellular levels of DOPAC and HVA within μ-OR knockout mice significantly differed from the wild-type controls. The duration of recovery to the basal levels of extracellular DA and 5-HT metabolites induced by MA were much longer in wild-type mice than for μ-OR knockout mice. These findings suggest that μ-ORs play a modulatory role in MA-induced DA and 5-HT metabolism in the mouse striatum. This possible mechanism of MA-induced behavioral change as modulated by μ-OR merits further study.
- 中文關鍵字: --
- 英文關鍵字: methamphetaraine, μ-opioid receptor, dopamine and serotonin metabolites, striatum, microdialysis