• 作者： 吳香達; 許麗美; 梁華英; 陳正益
• 作者服務機構： Department of Obstetrics & Gynecology Veterans General Hospital and National Yang-Ming Medial College; Department of Chemistry Soo-Chow University
• 中文摘要： 從100位懷孕15至37週待產的孕婦取得100個羊水標本，同時用液態層析法(high performance liquid chromato-graphy； HPLC)及薄層法(thin layer chromatography； TLC)測定卵磷質和神經磷質的比值(lecithin/sphingomyelin rati-o)。 結果分成兩組：比值等或大於2，比值小於2。80個用HPLC檢查的羊水標本，當比值等或大於2時，只有一個或1.3%新生兒發生呼吸窘迫症(respiratory distress syndrome; RDS)； 65個用TLC檢查，比值也大於2時，卻有兩個或3.1%的新生兒發生RDS。這兩者比較沒有統計意義。可是當比值小於2時，20個用HPLC測定的，有17個發生RDS，準確性達85%；35個用TLC測定的，只有16個發生RDS，準確性只有46.7%。這兩者比較，甚有臨床意義。換言之，在比值小於2時，用HPLC來預測新生兒RDS的發生，比較傳統用的TLC為準確。
• 英文摘要： One hundred amniotic fluid (AF) specimens of women at 28 to 37 weeks gestation were obtainedduring labor for lecithin/sphingomyelin ratio (L/S ratio) study by using high performance liquid chroma-tography (HPLC) and thin layer chromatography (TLC). The results are divided into two groups: one with L/S ratio at or more than 2, and the other withL/S ratio of less than 2. Of the 80 measured by HPLC with the ratio of above 2 or 1.3%, one sufferedrespiratory distress syndrome (RDS); of the 65 measured by TLC also with the ratio of above 2 or 3.1%,two developed RDS. The result bears no great significance here. However, in the groups with L/S ratioof less than two, the results were very significant: 17 of 20 estimated by HPLC happened to have RDSfor an incidence of false positive rate of 15% compared with a 54.3% in 16 of the 35 women evaluated byTLC.
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