- 作者: 潘文彬、魏麗梅、魏麗蘭、吳志中、吳永昌
- 作者服務機構: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
- 中文摘要: A convenient and useful esterification was realized, and this reaction proceeded without a dehydrating reagent or water removal equipment. A series of ortho-hydroxyphenyl carboxylic acids and benzoic acids were transformed to their corresponding methyl esters under CAN/CH3OH reaction conditions. Whereas in an aprotic solvent, acetonitrile, sp3-C tethered ortho-hydroxyphenyl carboxylic acids undergo simultaneous o,p-dinitration and intramolecular esterification reactions in good yields. Also, 2-((1E)-2-nitrovinyl)-4-nitrophenol (3e) showed selective cytotoxicities toward MCF-7, HEP G2, and HEP 3B cell lines with IC50 values of 23.50, 7.33, and 7.59 ug/mL, respectively.
- 英文摘要: --
- 中文關鍵字: Esterification; Nitration; Carboxylic acids; Cerium(IV) ammonium nitrate.
- 英文關鍵字: --