- 作者: 田明朋
- 作者服務機構: Contribution from the Department of Chemistry, Cheng Kung University, Tainan, Taiwan, Republic of China
- 中文摘要: The reaction of excess dimethyl sulfoxide with ethyl bromoacetate has been shown to produce ethyl glyoxylate, hydrogen bromide, and dimethyl sulfide. The yield of glyoxylate at first was reduced because the dimethyl sulfide reacted with bromoacetate to form trimethylsulfonium beomide and ethyl (methylmercapto) acetate, presumably via carbethoxymethyldimethylsulfonium bromide. These side reactions were diminished in a thin-film reactor, but the result was not satisfiable, the yield was 51%, and the side reactions were prevented by addition of methyl bromide, which rapidly consumed the dimethyl sulfide with formation of trimethlsulfonium bromide. Addition of 1, 2-epoxy-3-phenoxypropane removed the hydrogen bromide, thereby preventing the deleterious effects casued by its reduction of dimethyl sulfoxide to dimethyl sulfide. In this way has been developed a convenient preparation of ethyl glyoxylate in yields averaging about 70%. Identification and stoichiometry of the reaction products are presented.
- 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --