- 作者: Anuradha Subramanian; Uma Maheswari Krishnan; Swaminathan Sethuraman
- 作者服務機構: Center for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA University, Thanjavur, India
- 中文摘要: --
- 英文摘要:
Neural tissue repair and regeneration strategies have received a great deal of attention
because it directly affects the quality of the patient’s life. There are many scientific
challenges to regenerate nerve while using conventional autologous nerve grafts and from
the newly developed therapeutic strategies for the reconstruction of damaged nerves.
Recent advancements in nerve regeneration have involved the application of tissue
engineering principles and this has evolved a new perspective to neural therapy. The
success of neural tissue engineering is mainly based on the regulation of cell behavior
and tissue progression through the development of a synthetic scaffold that is analogous
to the natural extracellular matrix and can support three-dimensional cell cultures. As the
natural extracellular matrix provides an ideal environment for topographical, electrical
and chemical cues to the adhesion and proliferation of neural cells, there exists a need to
develop a synthetic scaffold that would be biocompatible, immunologically inert,
conducting, biodegradable, and infection-resistant biomaterial to support neurite
outgrowth. This review outlines the rationale for effective neural tissue engineering
through the use of suitable biomaterials and scaffolding techniques for fabrication of a
construct that would allow the neurons to adhere, proliferate and eventually form nerves. - 中文關鍵字: --
- 英文關鍵字: --