- 作者: I-Ling Lin, I-Hsiang Chen, Chi-Fong Lin, Yu-Hsiang Lo, Sheng-Huei Yang, Shinne-Ren Lin and Ming-Jung Wu*
- 作者服務機構: Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
- 中文摘要: A series of 1-(6-(2-(2-arylethynyl)phenyl)hexyn-5-yl)piperidin-2-ones 2a-j were synthesized and their antitumor activities were evaluated. Of these compounds, 1-(6-(2-(2-(4-nitrophenyl)ethynyl)phenyl)hexyn-5-yl)piperidin-2-one (2j) showed the highest potency of growth inhibition activity, especially against the RPMI-8226 (0.4 μM) and SR (0.02 μM) cell lines of human leukemia. Compound 2j also induced significant apoptotic progress in the cell cycle assay with the K-562 cell line.
- 英文摘要: --
- 中文關鍵字: Enediyne; Antitumor; Apoptosis.
- 英文關鍵字: --