• 作者： 廖楓; 黃伯超
• 作者服務機構： 國立臺灣大學醫學院生化學科
• 中文摘要： 國人的核黃素一直不足，而油脂攝取量近年來亦增加許多。由於脂肪酸之代謝需要核黃素輔?，本研究則探討核黃
  素的中度缺乏，對攝食高脂肪，中量脂肪飼料的大白鼠其體內脂質代謝，是否具有不良之影響。剛斷乳的Wistar種幼鼠
  30隻，先餵予無核黃素飼料一個月後，將其分為六組（每一組5隻），分別給予不同核黃素含量（每100g飼料含0.1或
  0.3mg）及不同脂肪含量（佔總熱量的10%，25%及40%）的實驗飼料，以配對飼育(pair-feeding)的方式餵養五個星期
  。最後一天斷頭取血及肝臟以做各種分析。結果顯示，核黃素不足組，其紅血球Glutathione reductase致活比係數顯著
  地升高（P<0.05 ～ P<0.005）。在高脂肪且核黃素缺乏組，其食物利用效率較差，明顯的生長不良（P<0.05）和肝臟重
  量（每100g體重）的增加（P<0.001）。且肝臟總脂質（P<0.025），三甘油酯（P<0.025），膽固醇（P<0.05）及脂質過氧
  化物（P<0.025）含量皆比對照組顯著地升高。血清脂質在核黃素缺乏之各組有偏低的趨勢，但只在中量脂肪組，其血清
  總脂質及膽固醇濃度之降低具有顯著差異性（P<0.05）。本研究結果顯示，攝取高脂肪且核黃素缺乏的飼料會使脂質代
  謝不正常。e
• 英文摘要： Dietary riboflavin intake of the people in Taiwan has been inadequate, while the fat intake has beenincreasing remarkably in recent years. Therefore, the effects of a moderate riboflavin deficiency on lipidmetabolism in growing young rats fed diets containing 10, 25, or 40 percent calories of fat for 5 weekswere studied. The riboflavin deficiency status of the rats was certified by increased activity coefficientsof erythrocyte glutathione reductase. Serum total lipids and cholesterol levels were significantly lower(P < 0.05) in the medium fat-riboflavin deficient group. In the high fat-riboflavin deficient group, thegrowth and dietary intake were depressed and the liver weight/100 g body weight increased markedly (P< 0.001). The liver total lipids, triglycerides, cholesterol and lipid peroxides of the high fat-riboflavindeficient group showed significant increases (P < 0.025, P < 0.025, P < 0.05 and P < 0.025 respectively),as compared with the pair-fed control groups. However, the increases were not significant in the mediumfat and the low fat groups. The present study indicates that a high fat-riboflavin deficient diet wouldhave adverse effects on lipid metabolism.
• 中文關鍵字： ribofiavin deficiency; high fat diet; lipid metabolism
• 英文關鍵字： --