• 作者： Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova and Jan Rosocha
• 作者服務機構： 1. Associated Tissue Bank, Faculty of Medicine, P. J. Safarik University in Kosice, Tr. SNP 1, 04011, Kosice, Slovakia
• 中文摘要：
• 英文摘要：
  Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily cultured and manipulated. Recent investigations revealed that their therapeutic effect is largely mediated by the secretion of paracrine factors including exosomes. Exosomes reflect biophysical features of MSCs and are considered more effective than MSCs themselves. Alternative approaches based on MSC-derived exosomes can offer appreciable promise in overcoming the limitations and practical challenges observed in cell-based therapy. Furthermore, MSC-derived exosomes may provide a potent therapeutic strategy for various diseases and are promising candidates for cell-based and cell-free regenerative medicine. This review briefly summarizes the development of MSCs as a treatment for human diseases as well as describes our current knowledge about exosomes: their biogenesis and molecular composition, and how they exert their effects on target cells. Particularly, the therapeutic potential of MSC-derived exosomes in experimental models and recent clinical trials to evaluate their safety and efficacy are summarized in this study. Overall, this paper provides a current overview of exosomes as a new cell-free therapeutic agent.
• 中文關鍵字：
• 英文關鍵字： Mesenchymal stem cells, Exosomes, Cell-free therapy, Therapeutic potential