• 作者： 趙德讓; 張治平; 張溟滄; 劉宏璋; 王約翰; 尹士俊
• 作者服務機構： 三軍總醫院病理部及醫學研究部; 國防醫學院生化研究所; 榮民總醫院病理部
• 中文摘要： 應用瓊膠等電焦集及澱粉膠電泳怯分別鑑定71個國人遺體剖驗肝臟的醇去氫?（ADH）和醛去氫?（ALDH）之同功
  ?表現型。90%肝臟的均質上清液氧化乙醇最適pH值在8.5,10%在10.5，後者係屬於西方人族群中常見之同型接合體
  (方程式無法摘錄) 1-1表現型。前者之中，59%屬於同型接合體 (方程式無法摘錄) 2-2表現型，31％係屬異型接合體 (方程式無法摘錄) 2-1表現型。 (方程式無法摘錄) 和
  (方程式無法摘錄) 對偶質的基因頻數因此分別是0.75和0.25。在所檢測的71個肝臟之中，58％同時具有ALDH I和ALDH II同功
  ?的活性，42%則缺少ALDH I的活性。文中討論東方人這種肝臟ADH和ALDH同功?不同表現型的分佈和乙醇在體
  內排除，對乙醇的敏感性及酒癮之間的關連和意義。
  較
• 英文摘要： Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isoenzyme phenotypes weredetermined in 71 autopsy liver specimens by agarose isoelectric focusing and starch gel electrophoresis,respectively. Ninety percent of the livers examined exhibited a pH-optimum for ethanol oxidation at pH8.5, instead of 10.5 which is usual among Caucasians. The homozygous (方程式無法摘錄) 2-2 phenotype was foundto be 59%, and the heterozygous (方程式無法摘錄) 2-1 phenotype, 31%. The remaining 10% of the livers, exhibitinga pH-optimum at 10.5, were homozygous (方程式無法摘錄) 1-1 phenotype. Accordingly, the gene frequencies of thealleles (方程式無法摘錄) and (方程式無法摘錄) were calculated to be 0.75 and 0.25, respectively. Fifty-eight percent of the 71livers examined possessed both the activities of ALDH I and ALDH II isoenzymes, whereas 42% lacked theALDH I activity. The implications of these distributions of liver ADH and ALDH isoenzyme patternsamong Orientals for ethanol elimination, alcohol sensitivity and alcoholism are discussed.
• 中文關鍵字： human liver; alcohol dehydrogenase; alaehyde dehydrogenase; isoenzyme; polymor-phism
• 英文關鍵字： --