- 作者: Ben Berkhout
- 作者服務機構: Department of Human Retrovirology, Acdemic Medical center, Amsterdam, The Netherlands
- 中文摘要: --
- 英文摘要: The human immunodeficiency virus(HIV-1)has evolvedinto a viral quasispecies with a high replication capacityorfitness. Antiretroviral drugs potently inhibit replicationof the wild-type virus, but HIV-1 responds by selection ofdrug-resistant variants. Here we review, in brief, the evo-lution of resistance to protease inhibitors that is charac-terized by severe fitness losses and an abundance ofsubsequent repair strategies. The possibility to restrictHIV-1 fitness is discussed in relation to the control ofHIV-1 pathogenesis.
- 中文關鍵字: --
- 英文關鍵字: Human immunodeficiency virus. Protease inhibitors. Drug Resistance. Virus evolution. Viral fitness. Second-site suppranslational frameshift. Gag-Pol protein processing