- 作者: 王光燦;陳水田;黃敏哲;張傳?
- 作者服務機構: 中央研究院生物化學研究所; 國立臺灣大學醫學院藥理學科
- 中文摘要: 甲硫丁胺酸-安?啡?及白胺酸-安?啡?以液相法合成。先合成三胜呔Tyr-Gly-Gly後,再與二胜呔Phe-Leu或Phe-Met 分別合成,可得?收量之五胜呔,且無旋消現象之慮。此二種嗎啡作用五胜呔以天竺鼠之回腸、中樞及末梢實驗所得的 生理活性與天然物相同。實驗結果並顯示天竺鼠回腸有內在安?啡?存在。
- 英文摘要: Leu- and Met-enkephalins, two natural opioid pentapeptides, were synthesized by solution method. Synthesis of Tyr-Gly-Gly and subsequent coupling with either Phe-Leu-OMe or Phe-Met-OMe were performed with high yields. The synthetic pentapeptides showed similar effects, both central and peripheral, as previously reported. The presence of endorphin in the guinea-pig ileum was suggested.
- 中文關鍵字: --
- 英文關鍵字: --