- 作者: Wagnat W. Wardkhan,* Mohamed A. Youssef, Faten I. Hamed and Salama A. Ouf
- 作者服務機構: National Organization for Drug Control & Research, P. O. 29, Cairo, A. R. Egypt
- 中文摘要: The 2-ethoxy carbonyl methylene thiazol-4-one (3) reacts with acetophenone (4) to give the ethyl 2-(4-oxo-4,5-dihydro-thiazol-2-yl)-3-phenyl-2-butenoate (5). The reactivity of the latter product towards aromatic aldehydes 6a-d, cyanomethylene reagents 9a,b, aromatic aldehydes 13a-d, phenylisothiocyanate (16), elemental sulfur and aromatic amines (20a-c) was studied to give arylidene, pyridine, thiophene and anilide derivatives. Some of the newly synthesized derivatives were used to synthesize fused derivatives. The antimicrobial activities of the newly synthesized products were tested in vitro for antimicrobial activity against two bacterial isolates, one saprophytic (Escherichia coli) and the other parasitic (Xanthomonas citri) and for antifungal activity against one saprophytic (Aspergillus fumigatus) and two phytopathogenics (Rhizoctonia solani and Fusarium oxysporum).
- 英文摘要: --
- 中文關鍵字: Thiazole; Pyrazole; Pyridazine; Antimicrobial.
- 英文關鍵字: --