- 作者: Pravin Kumar Singh, Ajay Vir Singh and Devendra Singh Chauhan
- 作者服務機構: Department of Microbiology & Molecular Biology, National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Tajganj, Agra (UP) Pin- 282001, India
- 中文摘要: --
- 英文摘要: MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Due to involvement in a broad range of biological processes and diseases, miRNAs are now commanding considerable attention. Although much of the focus has been on the role of miRNAs in different types of cancer, recent evidence also points to a critical role of miRNAs in infectious disease, including those of bacterial origin. Now, miRNAs research is exploring rapidly as a new thrust area of biomedical research with relevance to deadly bacterial diseases like Tuberculosis (caused by Mycobacterium tuberculosis). The purpose of this review is to highlight the current developments in area of miRNAs regulation in Mycobacterial diseases; and how this might influence the diagnosis, understanding of disease biology, control and management in the future.
- 中文關鍵字: --
- 英文關鍵字: Micro-RNA, Mycobacterial infection, Tuberculosis, Mycobacterium tuberculosis