- 作者: 吳信隆 ; 吳秀梅 ; 陳素惠
- 作者服務機構: 高雄醫學院藥學研究所
- 中文摘要: Chiral separation of reduced haloperidol (RHP), an optically active metabolite from haloperidol, by capillary electrophoresis is described. RHP was separated on an uncoated capillary with dimethyl-.beta.-cyclodextrin(dimethyl-.beta.-CD) in Tris phosphate buffer using PEG 6000 as an organic additive. Several parameters affecting the separation of RHP were studied, including pH and concentration of buffer, buffer additive, and concentration of chiral selector. The migration order of the resolved RHP was assigned with reference RHP enantiomers.
- 英文摘要: --
- 中文關鍵字: Haloperidol; Capillary Electrophoresis; Cyclodetrin; Enantioseparation; Ph; Buffer Additive
- 英文關鍵字: 哈泊度;毛細管電泳;環糊精;對映異構物分離;pH值;緩衝溶液添加劑