- 作者: Ola Salhab, Luna Khayat & Nada Alaaeddine
- 作者服務機構: 1.Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon 2.Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon 3.University of Ottawa, Faculty of Science, Ottawa, ON, Canada
- 中文摘要:
- 英文摘要:
Background: Living organisms are continuously exposed to multiple internal and external stimuli which may infuence their emotional, psychological, and physical behaviors. Stress can modify brain structures, reduces functional
memory and results in many diseases such as skin disorders like acne, psoriasis, telogen efuvium, and alopecia
areata. In this review, we aim to discuss the efect of secretome on treating alopecia, especially alopecia areata. We
will shed the light on the mechanism of action of the secretome in the recovery of hair loss and this by reviewing all
reported in vitro and in vivo literature.
Main body: Hair loss has been widely known to be enhanced by stressful events. Alopecia areata is one of the skin
disorders which can be highly induced by neurogenic stress especially if the patient has a predisposed genetic background. This condition is an autoimmune disease where stress in this case activates the immune response to attack
the body itself leading to hair cycle destruction. The currently available treatments include medicines, laser therapy,
phototherapy, and alternative medicine therapies with little or no satisfactory results. Regenerative medicine is a new
era in medicine showing promising results in treating many medical conditions including Alopecia. The therapeutic
efects of stem cells are due to their paracrine and trophic efects which are due to their secretions (secretome).
Conclusion: Stem cells should be more used as an alternative to conventional therapies due to their positive outcomes. More clinical trials on humans should be done to maximize the dose needed and type of stem cells that must
be used to treat alopecia areata - 中文關鍵字:
- 英文關鍵字: Stress, Hair loss, Alopecia areata, Stem cell secretome, Mechanism of restoring hair loss, Hair regeneration, Hair growth, Regenerative therapy/medicine