- 作者: 張大釗
- 作者服務機構: Institute of Atomic and Molecular Sciences, Academia Sinica, P. O. Box 23-166, Taipei 106, Taiwan, R.O.C.
- 中文摘要: A new molecule of 3,6-Bis(1-methyl-4-vinylpyridium iodine)carbazole (BMVC) was synthesized for stabilizing the quadruplex structure of human telomeric sequence of d(T2AG3)4 in vitro. Mixing BMVC with the DNA can raise the melting temperature of the d(T2AG3)4 by ~ 13 °C, implying that BMVC could be a useful telomerase inhibitor. In addition, the fluorescence of the BMVC increased significantly upon interacting with the d(T2AG3)4 which may be useful as a G-quadruplex specific marker.
- 英文摘要: --
- 中文關鍵字: Human telomere; Quadruplex stabilizer; Biomarker.
- 英文關鍵字: Human telomere; Quadruplex stabilizer; Biomarker.