- 作者: Sheng Wang-Wuu; Yu-Ming Lai; Wuh-Liang Hwu; Tso-Ren Wang; Kuang-Dong Wuu
- 作者服務機構: a Institute of Genetics, National Yang Ming; Medical College, and; b Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要: 560 blood samples collected from mentally retarded children in Taipei were karyotypically analyzed for the incidence of fragile X and other chromosome abnormalities. The fragile site at Xq27.3 was observed in 18 patients (3.21%) 11 males and 7 females, out of the 560 blood cultures using M medium. Down syndrome (6.25%), 24 males and 11 females, was the other major category of abnormality. Other abnormalities, including inversion, translocation, dele- tion, duplication, ring as well as an extra marker chromosome were observed. The overall incidence of chromosomal abnormalities in these children was 14.82%.
- 中文關鍵字: --
- 英文關鍵字: Fragile X; Chromosome abnormalities; Mental retardation