- 作者: Jen-Wei Chen; Kuo-Huang Ling
- 作者服務機構: Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要: Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus, potently and noncompetitively inhibited Electrophorus acetylcholinesterase (AChE EC 3.1.1.7), but had no inhibitory effect on horse serum butyrylcholin-esterase (BtChE EC 3.1.1.8). The TRB-treated AChE did not recover its enzyme activity after either dialysis or dilution of the inhibited enzyme. The binding of [14C]TRB to AChE, but not to BtChE, was demonstrated. The concentrations of territrems required for 50% inhibition of AchE were: TRA 2.4 x 10^-8M; TRB 1.9 x 10^-8M; TRC 1.5 x 10^-8M; TRA' 9.8 x 10^-8M; TRB'9.2 x 10^-8M.
- 中文關鍵字: --
- 英文關鍵字: Territrem; Acetylcholinesterase inhibitor