- 作者: Chen-Hsing Lina,b, Ching-Erh Lina, Chia-Chong Chena and Li-Fang Liaob
- 作者服務機構: Department of Chemistry, National Taiwan University, Taipei, Taiwan, R.O.C.
- 中文摘要: A silica-base chiral stationary phase (CSP) derived from L-alanyl- and piperidinyl-disubstituted cyanuric chloride was prepared for the enantioseparation of methyl esters of N-(3,5-dinitrobenzoyl)amino acids and amino alcohols. This CSP provides good chiral recognition and effective separation of enantiomers of both methyl esters of N-(3,5-dinitrobenzoyl)amino acids, except for proline, and N-(3,5-dinitrobenzoyl)amino alcohols by high-performance liquid chromatography. The enantioselectivity depends mainly on three preferential interactions which include a p-p interaction and two hydrogen-bonding interactions. However, steric interaction between substituents attached to the chiral center of chiral selectands and the chiral selector also plays a significant role in chiral recognition. Comparison of chromatographic results of the CSP prepared in this study with those of the CSP containing pyrrolidinyl group attached to the s-triazine moiety, reported previously (J. Chromatogr. A, 722 (1996) 189), reveals that influences of steric interaction and the basic nature of piperidinyl substituent attached to the s-triazine ring of the chiral selector on chiral discrimination may not be neglected.
- 英文摘要: --
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