- 作者: Sara Socorro Faria, Susan Costantini, Vladmir Cláudio Cordeiro de Lima, Victor Pianna de Andrade, Mickaël Rialland, Rebe Cedric, Alfredo Budillon and Kelly Grace Magalhães
- 作者服務機構: 1.Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia, Brasilia, DF, Brazil 2.Experimental Pharmacology Unit - Laboratory of Mercogliano (AV), Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, 80131, Naples, Italy 3.Department of Medical Oncology and Laboratory of Translational Immuno-Oncology, A.C. Camargo Cancer Center, São Paulo, Brazil 4.Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil 5.Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1231, 21000, Dijon, France 6.UFR Sciences de la Vie, Terre et Environnement, Université de Bourgogne Franche-Comté, 21000, Dijon, France 7.Platform of Transfer in Cancer Biology, Centre Georges François Leclerc, 21000, Dijon, France
- 中文摘要:
- 英文摘要:
Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing its progression, metastatic potential and therapeutic outcome by altering the tumor immune microenvironment. These processes are mediated by a variety of cytokines, chemokines and growth factors that exert their biological functions either locally or distantly. Inflammasomes are protein signaling complexes that form in response to damage- and pathogen-associated molecular patterns (DAMPS and PAMPS), triggering the release of pro-inflammatory cytokines. The dysregulation of inflammasome activation can lead to the development of inflammatory diseases, neurodegeneration, and cancer. A crucial signaling pathway leading to acute and chronic inflammation occurs through the activation of NLRP3 inflammasome followed by caspase 1-dependent release of IL-1β and IL-18 pro-inflammatory cytokines, as well as, by gasdermin D-mediated pyroptotic cell death. In this review we focus on the role of NLRP3 inflammasome and its components in breast cancer signaling, highlighting that a more detailed understanding of the clinical relevance of these pathways could significantly contribute to the development of novel therapeutic strategies for breast cancer. - 中文關鍵字:
- 英文關鍵字: Breast cancer, Gasdermins, IL-1β, NLRP3 infammasome