- 作者: I.K. Kim, R.L. Copeland, Jr.; J.H. Lee, H.S. Kim; E. Asafo-Adjei, N.D. Brown; J.S. Estrada, R.K. Gordon; G.E. Garcia, P.K. Chiang
- 作者服務機構: a Department of Biochemistry, Catholic; University Medical College, Seoul, Korea;; b Department of Pharmacology, Howard; University College of Medicine, and; c Walter Reed Army Institute of Research, Washington DC, USA
- 中文摘要: --
- 英文摘要: High concentrations of adenosine (Ado), when added to L1210 lymphocytic leukemia cells, resulted in apoptosis or programmed cell death. The apoptotic process was accompanied by distinct morphological changes including chro- matin condensation and blebbing of plasma membranes. Extensive DNA frag- mentation was correlated with Ado concentrations. Furthermore, apoptosis in these cells was preceded by an early but transient expression of c-myc proto- oncogene, and was not influenced by homocysteine thiolactone added to the cells. Since severe combined immunodeficiency (SCID) is associated with a deficiency of adenosine deaminase, leading to defects in both cellular and humoral immunity, Ado-induced apoptosis may thus be a contributing factor in the pathology of SCID.
- 中文關鍵字: --
- 英文關鍵字: Adenosine ; Adenosine deaminase deficiency ; Apoptosis ; c-myc ; DNA fragmentation ; Proto-oncogene ; L1210 lymphocytic leukemia cells ; Severe combined immunodeficiency ; syndrome